SUSAN H. SENNETT, Ph.D.

sennett@hboi.edu

(University of Delaware, Graduate College of Marine Studies, 1991 - Marine Studies)

Research interests include determination of the biogenetic origin of bioactive metabolites from tropical deep water sponges and the use of invertebrate cell culture as a sustainable source of bioactive metabolites. Other research interests include the role of bioactive metabolites in the marine environment and the potential use of natural products in sponge systematics.

Selected Publications:

Pomponi, S.A., R. Willoughby, A. E. Wright, C. Pecorella, S. H. Sennett, J. Lopez, and G. Samples. (1998) Chapter 15. In vitro production of marine-derived antitumor compounds. IN: New Developments in Marine Biotechnology (Y. Le Gal and H. O. Halvorson, eds.), Plenum Press, New York, pp. 73-76.

Gunasekera, S.P., S.H. Sennett, K.E. Janda, and R.W. Bryant. 1995. Bioassay-guided isolation and identification of linoleic acid, a guanosine diphosphate/G protein RAS exchange (GDPX) assay active compound from HBOI strain D245. Intl. J. Pharmacognosy. 33:256-258

Gunasekera, S.P., S.H. Sennett, Michelle Kelly-Borges, and R.W. Bryant. 1994. Ophirapstanol Trisulfate, a new biologically active steroid sulfate from the deep water marine sponge Topsentia ophiraphidites. J. Nat. Prod. 57:1751-1754.

Sennett, S.H., S.A. Pomponi, and A.E. Wright. 1992. Diterpene metabolites from two chemotypes of the marine sponge Myrmekioderma styx. J. Nat. Prod. 55: 1421-1429.